Minimal residual disease in childhood acute lymphoblastic leukaemia.

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

The clinical relevance of detection of minimal residual disease in childhood acute lymphoblastic leukaemia

Risk directed treatment forms a central component of modern protocols for childhood acute lymphoblastic leukaemia (ALL). A review of recent studies of minimal residual disease (MRD) analysis shows that it is a powerful prognostic factor in both first line and relapse treatment. However, the value of MRD analysis is both time point and protocol specific, and the threshold for MRD detection of th...

The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia

Background: Malignant disorder with B or T stem cell basis leads to development and continuation of acute lymphoblastic leukemia (ALL) due to aggregation of blast cells in bone marrow. The environmental, genetic, and demographic factors may influence the disease relapse. The objective of this study was to assess the relation between end of induction minimal residual disease and different risk f...

Immunoglobulin gene rearrangement in detection of minimal residual disease in acute lymphoblastic leukaemia.

BACKGROUND Acute lymphoblastic leukaemia (ALL) is mainly a childhood malignancy but affects both children and adults. OBJECTIVE The study was conducted to evaluate a qualitative PCR based method for detection of clonal immunoglobulin gene rearrangement as a marker of minimal residual disease in patients of acute lymphoblastic leukaemia at the end of induction. METHOD It was a descriptive st...

Stressful life events and childhood illness.

The use of DNA probes to monitor minimal residual disease in childhood acute lymphoblastic leukaemia. A. The polymerase chain reaction: a new tool for the detection of minimal residual disease in hae-matological malignancies. Tournay 0, et al. Detection of minimal disease in hematopoietic malignancies of the B lineage by using third-complimentarity-determining region (CDR-III) specific probes. ...